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Issue 7, 2009
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Advancing high-throughput gene synthesis technology

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The emerging field of synthetic biology is generating insatiable demands for synthetic genes, which far exceed existing gene synthesis capabilities. This review discusses the current methods of chemical DNA synthesis and gene assembly, as well as the latest engineering tools, technologies and trends which could potentially lead to breakthroughs in the development of accurate, low-cost and high-throughput gene synthesis technology. The capability of generating unlimited supplies of DNA molecules of any sequence or size will transform biomedical research in the near future.

Graphical abstract: Advancing high-throughput gene synthesis technology

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Publication details

The article was received on 10 Dec 2008, accepted on 11 Feb 2009 and first published on 06 Apr 2009

Article type: Review Article
DOI: 10.1039/B822268C
Citation: Mol. BioSyst., 2009,5, 714-722
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    Advancing high-throughput gene synthesis technology

    J. Tian, K. Ma and I. Saaem, Mol. BioSyst., 2009, 5, 714
    DOI: 10.1039/B822268C

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