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Issue 5, 2009
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Diversity-oriented fluorescence library approach for the discovery of sensors and probes

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Abstract

Fluorescent small molecules have received considerable attention due to their potential for chemosensing and bioimaging. A conventional strategy for probe development is a target-oriented approach based on known molecular recognition mechanisms for individual analytes. However, sophisticated rational design does not always guarantee the applicability of probes in complex biological systems. Therefore the speed and the scope of sensor development has been limited. To overcome these limitations, diversity-oriented fluorescence library approaches have been applied to develop new fluorescent probes in the absence of knowledge about the target recognition mechanism. This review summarizes recent advances in fluorescent probe development facilitated by diversity-oriented library approaches.

Graphical abstract: Diversity-oriented fluorescence library approach for the discovery of sensors and probes

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Publication details

The article was received on 03 Dec 2008, accepted on 23 Jan 2009 and first published on 11 Mar 2009


Article type: Review Article
DOI: 10.1039/B821766C
Citation: Mol. BioSyst., 2009,5, 411-421
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    Diversity-oriented fluorescence library approach for the discovery of sensors and probes

    J. Lee, Y. K. Kim, M. Vendrell and Y. Chang, Mol. BioSyst., 2009, 5, 411
    DOI: 10.1039/B821766C

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