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Issue 10, 2009
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Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium

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Abstract

A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old rats and TFE-administered rats have been profiled by LC/MS. Thirty age-related endogenous metabolites were discovered by partial least squares (PLS) and Hotelling’s T2 control chart, among which 25 metabolites were structurally identified by MSn analysis and ten of them were further confirmed via authentic chemicals. All important age-related metabolites, such as unsaturated fatty acids, saturated fatty acids, nucleotides, carnosine, ergothioneine and amino acids, displayed age-related changes, and most of them were reset to a younger level after TFE administration. This study indicated that aging could be characterized by changes of lipid metabolisms and accumulation of free radicals. The anti-aging effects of TFE might due to the intervention on lipid metabolism and its property of anti-oxidation.

Graphical abstract: Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium

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Publication details

The article was received on 18 Sep 2008, accepted on 05 Jun 2009 and first published on 14 Jul 2009


Article type: Paper
DOI: 10.1039/B816407J
Citation: Mol. BioSyst., 2009,5, 1204-1213
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    Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium

    S. Yan, B. Wu, Z. Lin, H. Jin, J. Huang, Y. Yang, X. Zhang, Z. Shen and W. Zhang, Mol. BioSyst., 2009, 5, 1204
    DOI: 10.1039/B816407J

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