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Issue 4, 2009
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Protein lethality investigated in terms of long range dynamical interactions

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Abstract

The relationship between network structure/dynamics and biological function constitutes a fundamental issue in systems biology. However, despite many related investigations, the correspondence between structure and biological functions is not yet fully understood. A related subject that has deserved particular attention recently concerns how essentiality is related to the structure and dynamics of protein interactions. In the current work, protein essentiality is investigated in terms of long range influences in proteinprotein interaction networks by considering simulated dynamical aspects. This analysis is performed with respect to outward activations, an approach which models the propagation of interactions between proteins by considering self-avoiding random walks. The obtained results are compared to protein local connectivity. Both the connectivity and the outward activations were found to be strongly related to protein essentiality.

Graphical abstract: Protein lethality investigated in terms of long range dynamical interactions

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Publication details

The article was received on 08 Sep 2008, accepted on 19 Jan 2009 and first published on 24 Feb 2009


Article type: Paper
DOI: 10.1039/B815702M
Citation: Mol. BioSyst., 2009,5, 385-390
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    Protein lethality investigated in terms of long range dynamical interactions

    F. A. Rodrigues and L. D. F. Costa, Mol. BioSyst., 2009, 5, 385
    DOI: 10.1039/B815702M

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