Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

Jonathan Swann; Yulan Wang; Leticia Abecia; Adele Costabile; Kieran Tuohy; Glenn Gibson; David Roberts; James Sidaway; Huw Jones; Ian D. Wilson; Jeremy Nicholson; Elaine Holmes

doi:10.1039/B811468D

skip RSC | ChemSpider | Feedback

Home > Journals > Molecular BioSystems > Gut microbiome modulate...

Authors & Referees | Librarians

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Molecular BioSystems

Issue 4, 2009

More about this Journal
Editorial Board
Submit an Article

Follow Journal | |

Journal Home | RSC Journals

Communication

Previous Article | Next Article

Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

Jonathan Swann , Yulan Wang , Leticia Abecia , Adele Costabile , Kieran Tuohy , Glenn Gibson , David Roberts , James Sidaway , Huw Jones , Ian D. Wilson , Jeremy Nicholson and Elaine Holmes

Mol. BioSyst., 2009, 5, 351-355

DOI: 10.1039/B811468D
Received 07 Jul 2008, Accepted 08 Dec 2008
First published on the web 23 Jan 2009

Please wait while Download options loads

Request Permissions

Abstract
Cited by
Compounds
Related Content

The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and ‘conventional’ Sprague Dawley rats using ¹H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

This may take some time to load.

Terms & Conditions|Privacy |Accessibility|ACAP Enabled

Molecular BioSystems

Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

Log in (Free Access)

Log in (Subscriber Access)

Supplementary Info

Articles By