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Issue 12, 2009
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Global signatures of protein and mRNA expression levels

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Abstract

Cellular states are determined by differential expression of the cell’s proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

Graphical abstract: Global signatures of protein and mRNA expression levels

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Publication details

The article was received on 27 Apr 2009, accepted on 22 Jul 2009 and first published on 01 Oct 2009


Article type: Review Article
DOI: 10.1039/B908315D
Citation: Mol. BioSyst., 2009,5, 1512-1526
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    Global signatures of protein and mRNA expression levels

    R. de Sousa Abreu, L. O. Penalva, E. M. Marcotte and C. Vogel, Mol. BioSyst., 2009, 5, 1512
    DOI: 10.1039/B908315D

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