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Issue 16, 2009
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An integrated microfluidic device for large-scale in situ click chemistry screening

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Abstract

An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions in parallel using the bovine carbonic anhydrous II (bCAII) click chemistry system as a proof-of-concept study and a rapid hit identification approach using SPE purification and electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves the sensitivity and throughput of the downstream analysis.

Graphical abstract: An integrated microfluidic device for large-scale in situ click chemistry screening

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Publication details

The article was received on 14 Apr 2009, accepted on 11 Jun 2009 and first published on 17 Jun 2009


Article type: Communication
DOI: 10.1039/B907430A
Citation: Lab Chip, 2009,9, 2281-2285
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    An integrated microfluidic device for large-scale in situ click chemistry screening

    Y. Wang, W. Lin, K. Liu, R. J. Lin, M. Selke, H. C. Kolb, N. Zhang, X. Zhao, M. E. Phelps, C. K. F. Shen, K. F. Faull and H. Tseng, Lab Chip, 2009, 9, 2281
    DOI: 10.1039/B907430A

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