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Issue 21, 2009
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Detection of prostate specific antigen with nanomechanical resonators

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Abstract

In this work, we use arrays of nanomechanical resonators to detect prostate specific antigen (PSA), a protein biomarker associated with prostate cancer. The surfaces of our very thin, trampoline-like devices are functionalised for immunospecific capture of PSA molecules, and the mass of bound material can be detected as a reduction in the resonant frequency. Fetal bovine serum was spiked with known concentrations of PSA, and in conjunction with a nanoparticle-based sandwich assay, concentrations as low as 50 fg mL−1, or 1.5 fM, could be detected from the realistic samples. The presence of non-specific proteins in the serum did not significantly affect the sensitivity of our assay.

Graphical abstract: Detection of prostate specific antigen with nanomechanical resonators

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Publication details

The article was received on 09 Apr 2009, accepted on 31 Jul 2009 and first published on 18 Aug 2009


Article type: Paper
DOI: 10.1039/B907309B
Citation: Lab Chip, 2009,9, 3095-3099
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    Detection of prostate specific antigen with nanomechanical resonators

    P. S. Waggoner, M. Varshney and H. G. Craighead, Lab Chip, 2009, 9, 3095
    DOI: 10.1039/B907309B

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