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Issue 19, 2009
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Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles

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Abstract

Superparamagnetic beads in giant unilamellar vesicles are used to facilitate magnetic manipulation, positioning, agitation and mixing of ultrasmall liquid volumes. Vesicles act as leakproof picoliter reaction vessels in an aqueous bulk solution and can be deliberately conveyed by an external magnetic field to a designated position. Upon application of an external magnetic field the beads align to form extended chains. In a rotating magnetic field chains break up into smaller fragments caused by the interplay of viscous friction and magnetic attraction. This process obeys a simple relationship and can be exploited to enhance mixing of the vesicle content and the outer solution or adjacent vesicle volumes exactly at the position of release.

Graphical abstract: Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles

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Publication details

The article was received on 25 Nov 2008, accepted on 24 Jun 2009 and first published on 06 Jul 2009


Article type: Paper
DOI: 10.1039/B906569P
Citation: Lab Chip, 2009,9, 2831-2835
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    Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles

    T. Franke, L. Schmid, D. A. Weitz and A. Wixforth, Lab Chip, 2009, 9, 2831
    DOI: 10.1039/B906569P

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