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Issue 12, 2009
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Microfluidic chip for combinatorial mixing and screening of assays

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Abstract

This paper reports the design, fabrication and validation of a microfluidic well plate for combinatorial screening applications. Each well within the array is comprised of two 200 picoliter compartments that each contain a photonic crystal biosensor to enable the on-chip, in situdetection of (bio-) molecular binding events. This microfluidic chip utilizes arrays of Actuate-to-Open valves to isolate all compartments, which allows the chip to be decoupled from pneumatic control lines and thus to be transported freely between filling, sensing and characterization platforms. A proof-of-principle 4 × 4 protein/antibody binding assay was performed to demonstrate the discrete mixing and on-chip sensing capabilities.

Graphical abstract: Microfluidic chip for combinatorial mixing and screening of assays

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Publication details

The article was received on 30 Jan 2009, accepted on 26 Mar 2009 and first published on 09 Apr 2009


Article type: Paper
DOI: 10.1039/B901999E
Citation: Lab Chip, 2009,9, 1676-1680
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    Microfluidic chip for combinatorial mixing and screening of assays

    B. R. Schudel, C. J. Choi, B. T. Cunningham and P. J. A. Kenis, Lab Chip, 2009, 9, 1676
    DOI: 10.1039/B901999E

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