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A microfluidic 3D hepatocyte chip for drug toxicity testing

Yi-Chin Toh,a   Teck Chuan Lim,a   Dean Tai,a   Guangfa Xiao,abc   Danny van Noort*a and   Hanry Yu*abdefgh  
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Corresponding authors
a
Institute of Bioengineering and Nanotechnology, A*STAR, The Nanos, #04-01, 31 Biopolis Way, Singapore, Singapore ;
Fax: +65 6478 9080 ;
Tel: +65 6824 7103
b
Department of Physiology, Yong Loo Lin School of Medicine, #03-03, 2 Medical Drive, Singapore, Singapore
c
Department of General Surgery, XiangYa Hospital, Central-South University, Changsha, China
d
Singapore-MIT Alliance, E4-04-10, 4 Engineering Drive 3, Singapore, Singapore
e
NUS Tissue-Engineering Programme, DSO Labs, National University of Singapore, Singapore, Singapore
f
Department of Haematology-Oncology, National University Hospital, Singapore, Singapore
g
Graduate Program in Bioengineering, NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), #05-01, 28 Medical Drive, Singapore, Singapore
h
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, USA
Lab Chip, 2009,9, 2026-2035

DOI: 10.1039/B900912D
Received 15 Jan 2009, Accepted 01 Apr 2009
First published online 20 Apr 2009
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