Lock release lithography for 3D and composite microparticles

Ki Wan Bong; Daniel C. Pregibon; Patrick S. Doyle

doi:10.1039/B821930C

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Lab on a Chip

Issue 7, 2009

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Lock release lithography for 3D and composite microparticles

Ki Wan Bong , Daniel C. Pregibon and Patrick S. Doyle

Lab Chip, 2009, 9, 863-866

DOI: 10.1039/B821930C
Received 08 Dec 2008, Accepted 04 Feb 2009
First published on the web 13 Feb 2009

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Abstract
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We present a method called “Lock Release Lithography (LRL)” that utilizes a combination of channel topography, mask design, and pressure-induced channel deformation to form and release particles in a cycled fashion. This technique provides a means for the high-throughput production of particles with complex 3D morphologies and composite particles with spatially configurable chemistries. In this work, we demonstrate a diverse set of functional particles including those displaying heterogeneous swelling characteristics and containing functional entities such as nucleic acids, proteins and beads.

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Details of the materials, the microfluidic device, thestop-flow lithography setup, and the photopolymerizationsetup.
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