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Issue 2, 2009
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Additional amplifications of SERSvia an optofluidic CD-based platform

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Abstract

In this paper, signal amplifications of surface-enhanced Raman scattering (SERS) are realized by an optofluidic compact disc (CD)-based preconcentration method for effective label-free environmental and biomolecular detections. The preconcentration of target molecules is accomplished through the accumulation of adsorbed molecules on SERS-active sites by repeating a ‘filling–drying’ cycle of the assay solution in the optofluidic CD platform. After 30 cycles, the clear and high SERS signal of rhodamine 6G of 1 nM is readily detected. In addition to the preconcentration-based signal amplification by the optofluidic SERS system on the CD platform, we introduce a controlled precipitation of gold nanoparticles by CuSO4 for SERS substrates. This method provides high-throughput, high-sensitive and large-area uniform SERS substrates on the optofluidic CD platform. The uniform SERS signals from different positions in spots of 3 mm2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates.

Graphical abstract: Additional amplifications of SERSvia an optofluidic CD-based platform

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Publication details

The article was received on 14 Jul 2008, accepted on 01 Sep 2008 and first published on 23 Oct 2008


Article type: Paper
DOI: 10.1039/B812067F
Citation: Lab Chip, 2009,9, 239-243
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    Additional amplifications of SERSvia an optofluidic CD-based platform

    D. Choi, T. Kang, H. Cho, Y. Choi and L. P. Lee, Lab Chip, 2009, 9, 239
    DOI: 10.1039/B812067F

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