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Issue 3, 2009
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A cooperative polymer-DNA microarray approach to biomaterial investigation

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Abstract

In this study, polymer microarrays were used for the rapid identification of polymer substrates upon which a suspension cell line would both adhere and proliferate giving a detailed and rapid understanding of cell-biomaterial interactions. Analysis demonstrated that suspension K562 human erythroleukemic cells, which normally grow in suspension, adhered and proliferated on several different polymers. Phenotypic and transcriptomic analysis techniques allowed examination of the interaction between cells and polymers permitting the elucidation of putative links between phenotypic responses to cell-biomaterial interactions and global gene expression.

Graphical abstract: A cooperative polymer-DNA microarray approach to biomaterial investigation

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Publication details

The article was received on 19 May 2008, accepted on 06 Oct 2008, published on 14 Nov 2008 and first published online on 14 Nov 2008


Article type: Paper
DOI: 10.1039/B808363K
Citation: Lab Chip, 2009,9, 397-403
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    A cooperative polymer-DNA microarray approach to biomaterial investigation

    S. Pernagallo, J. J. Diaz-Mochon and M. Bradley, Lab Chip, 2009, 9, 397
    DOI: 10.1039/B808363K

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