A cooperative polymer-DNA microarray approach to biomaterial investigation

Salvatore Pernagallo; Juan Jose Diaz-Mochon; Mark Bradley

doi:10.1039/B808363K

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Lab on a Chip

Issue 3, 2009

Miniaturisation for chemistry, physics, biology, materials science and bioengineering

Impact Factor 5.67 24 Issues per Year Indexed in MEDLINE

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Paper

A cooperative polymer-DNA microarray approach to biomaterial investigation

Salvatore Pernagallo,^a Juan Jose Diaz-Mochon^a and Mark Bradley*^a

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School of Chemistry, University of Edinburgh, Joseph Black Buildings, King's Building, West Main Road, Edinburgh, UK
E-mail: Mark.Bradley@ed.ac.uk ;
Fax: +44(0)1316506453 ;
Tel: + 44 (0)131 651 3307

Lab Chip, 2009,9, 397-403

DOI: 10.1039/B808363K
Received 19 May 2008, Accepted 06 Oct 2008
First published online 14 Nov 2008

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Abstract
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In this study, polymer microarrays were used for the rapid identification of polymer substrates upon which a suspension cell line would both adhere and proliferate giving a detailed and rapid understanding of cell-biomaterial interactions. Analysis demonstrated that suspension K562 human erythroleukemic cells, which normally grow in suspension, adhered and proliferated on several different polymers. Phenotypic and transcriptomic analysis techniques allowed examination of the interaction between cells and polymers permitting the elucidation of putative links between phenotypic responses to cell-biomaterial interactions and global gene expression.

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Supplementary Info

Monomers details (Table S1), primer sequences (Table S2),full polymers analysis (Table S3), list of significantly genes(Table S4), and pathway analysis (Table S5)
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