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Issue 3, 2009
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Sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding Bragg mirrors for enhanced sensitivity and isolation

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Abstract

We present nanohole arrays in thin gold films as sub-micron resolution surface plasmon resonance (SPR) imaging pixels in a microarray format. With SPR imaging, the resolution is not limited by diffraction, but by the propagation of surface plasmon waves to adjacent sensing areas, or nanohole arrays, causing unwanted interference. For ultimate scalability, several issues need to be addressed, including: (1) as several nanohole arrays are brought close to each other, surface plasmon interference introduces large sources of error; and (2) as the size of the nanohole array is reduced, i.e. fewer holes, detection sensitivity suffers. To address these scalability issues, we surround each biosensing pixel (a 3-by-3 nanohole array) with plasmonic Bragg mirrors, blocking interference between adjacent SPR sensing pixels for high-density packing, while maintaining the sensitivity of a 50× larger footprint pixel (a 16-by-16 nanohole array). We measure real-time, label-free streptavidin–biotin binding kinetics with a microarray of 600 sub-micron biosensing pixels at a packing density of more than 107 per cm2.

Graphical abstract: Sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding Bragg mirrors for enhanced sensitivity and isolation

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Publication details

The article was received on 24 Sep 2008, accepted on 21 Nov 2008 and first published on 19 Dec 2008


Article type: Paper
DOI: 10.1039/B816735D
Citation: Lab Chip, 2009,9, 382-387
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    Sub-micron resolution surface plasmon resonance imaging enabled by nanohole arrays with surrounding Bragg mirrors for enhanced sensitivity and isolation

    N. C. Lindquist, A. Lesuffleur, H. Im and S. Oh, Lab Chip, 2009, 9, 382
    DOI: 10.1039/B816735D

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