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Issue 36, 2009
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Synthesis, characterization and protein binding properties of supported dendrons

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Abstract

Novel benzylether type aldehyde and acetal terminated dendrons were synthesized and attached to a silica gel support; a linear spacer was also introduced as a control material. The supported dendritic compounds were mainly characterized by solid state 13C CPMAS NMR, elemental analysis and X-ray photoelectron spectroscopy (XPS) and the presence of free aldehydes was determined by the purpald test. Bovine serum albumin (BSA) protein was coupled to the dendronized support by imine bond formation, followed by irreversible reduction of the carbon–nitrogen double bond. A significant positive dendritic effect was observed on the antibody binding capacity of immobilised BSA as measured by fluorescence immunoassay (FIA).

Graphical abstract: Synthesis, characterization and protein binding properties of supported dendrons

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Publication details

The article was received on 22 Apr 2009, accepted on 11 Jun 2009 and first published on 10 Jul 2009


Article type: Paper
DOI: 10.1039/B908014G
Citation: J. Mater. Chem., 2009,19, 6616-6622
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    Synthesis, characterization and protein binding properties of supported dendrons

    O. Iliashevsky, L. Amir, R. Glaser, R. S. Marks and N. G. Lemcoff, J. Mater. Chem., 2009, 19, 6616
    DOI: 10.1039/B908014G

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