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Issue 36, 2009
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Biomedical applications of chemically-modified silk fibroin

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Abstract

Silk proteins belong to a class of unique, high molecular weight, block copolymer-like proteins that have found widespread use in biomaterials and regenerative medicine. The useful features of these proteins, including self-assembly, robust mechanical properties, biocompatibility and biodegradability can be enhanced through a variety of chemical modifications. These modifications provide chemical handles for the attachment of growth factors, cell binding domains and other polymers to silk, expanding the range of cell and tissue engineering applications attainable. This review focuses on the chemical reactions that have been used to modify the amino acids in silk proteins, and describes their utility in biomedical applications.

Graphical abstract: Biomedical applications of chemically-modified silk fibroin

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Publication details

The article was received on 23 Mar 2009, accepted on 22 May 2009 and first published on 23 Jun 2009


Article type: Application
DOI: 10.1039/B905802H
Citation: J. Mater. Chem., 2009,19, 6443-6450
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    Biomedical applications of chemically-modified silk fibroin

    A. R. Murphy and D. L. Kaplan, J. Mater. Chem., 2009, 19, 6443
    DOI: 10.1039/B905802H

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