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Issue 35, 2009
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Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo

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Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as T2-contrast agents for magnetic resonance imaging (MRI). Herein we develop various antibiofouling amphiphilic polymer-coated SPIONs using a one-step nanoemulsion method. This methodology yielded ultrasmall polymer-coated SPIONs, of average diameter less than 30 nm, which were stable under physiological conditions. In vitrocell cytotoxicity tests revealed that no SPION showed toxicity even at relatively high concentrations. In vivo MRI with Lewis lung carcinoma (LLC) tumor-bearing mice resulted in an approximately 30% T2 signal drop in tumor tissues, indicating that the SPIONs reached such tissues via passive targeting. In summary, the ultrasmall, stable, amphiphilic polymer-coated SPIONs can be used as MRI contrast agents for cancer imaging.

Graphical abstract: Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo

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Publication details

The article was received on 05 Feb 2009, accepted on 30 Apr 2009 and first published on 10 Jun 2009


Article type: Paper
DOI: 10.1039/B902445J
Citation: J. Mater. Chem., 2009,19, 6412-6417
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    Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo

    J. Park, M. K. Yu, Y. Y. Jeong, J. W. Kim, K. Lee, V. N. Phan and S. Jon, J. Mater. Chem., 2009, 19, 6412
    DOI: 10.1039/B902445J

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