Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

Amy L. Oldenburg; Matthew N. Hansen; Tyler S. Ralston; Alexander Wei; Stephen A. Boppart

doi:10.1039/B823389F

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Journal of Materials Chemistry

Issue 35, 2009

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Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

Amy L. Oldenburg , Matthew N. Hansen , Tyler S. Ralston , Alexander Wei and Stephen A. Boppart

J. Mater. Chem., 2009, 19, 6407-6411

DOI: 10.1039/B823389F
Received 06 Jan 2009, Accepted 06 Mar 2009
First published on the web 20 Apr 2009
This article is part of the collection: Inorganic nanoparticles for biological sensing, imaging and therapeutics

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Abstract
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Plasmon-resonant gold nanorods (GNRs) can serve as imaging agents for spectroscopic optical coherence tomography (SOCT). The aspect ratio of the GNRs is adjusted for maximum absorption in the far red to create a partial spectral overlap with the short-wavelength edge of the near-infrared SOCT imaging band. The spectroscopic absorption profile of the GNRs is incorporated into a depth-resolved algorithm for mapping the relative GNR density within OCT images. This technique enables us to image GNR distributions in excised human breast carcinomas, demonstrating their potential as OCT contrast agents in heterogeneous, highly scattering tissues.

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Amy L. Oldenburg
Matthew N. Hansen
Tyler S. Ralston
Alexander Wei
Stephen A. Boppart

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Journal of Materials Chemistry

Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

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