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Issue 35, 2009
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Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

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Abstract

Plasmon-resonant gold nanorods (GNRs) can serve as imaging agents for spectroscopic optical coherence tomography (SOCT). The aspect ratio of the GNRs is adjusted for maximum absorption in the far red to create a partial spectral overlap with the short-wavelength edge of the near-infrared SOCT imaging band. The spectroscopic absorption profile of the GNRs is incorporated into a depth-resolved algorithm for mapping the relative GNR density within OCT images. This technique enables us to image GNR distributions in excised human breast carcinomas, demonstrating their potential as OCT contrast agents in heterogeneous, highly scattering tissues.

Graphical abstract: Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

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Publication details

The article was received on 06 Jan 2009, accepted on 06 Mar 2009 and first published on 20 Apr 2009


Article type: Paper
DOI: 10.1039/B823389F
Citation: J. Mater. Chem., 2009,19, 6407-6411
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    Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

    A. L. Oldenburg, M. N. Hansen, T. S. Ralston, A. Wei and S. A. Boppart, J. Mater. Chem., 2009, 19, 6407
    DOI: 10.1039/B823389F

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