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Issue 18, 2009
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Toluidine blue-containing polymers exhibit potent bactericidal activity when irradiated with red laser light

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Abstract

Toluidine blue and toluidine blue-nanogold mixtures were incorporated into polyurethane and silicone polymers by a swell-encapsulation-shrink method using acetone-water mixtures. The surface and mechanical properties of the polymers were changed by the swell-shrink process especially the Young's modulus, but not by the introduction of toluidine blue or nanogold. The antibacterial properties of the various polymers were assessed under laser irradiation at 634 nm against Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA). The toluidine blue-incorporated polymers showed kills of (>105 cfu/ml) for MRSA after just one minute of exposure. This is, to our knowledge, the most potent light-activated antimicrobial polymer combination reported to date.

Graphical abstract: Toluidine blue-containing polymers exhibit potent bactericidal activity when irradiated with red laser light

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Publication details

The article was received on 17 Nov 2008, accepted on 09 Feb 2009 and first published on 09 Mar 2009


Article type: Paper
DOI: 10.1039/B820561B
Citation: J. Mater. Chem., 2009,19, 2715-2723
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    Toluidine blue-containing polymers exhibit potent bactericidal activity when irradiated with red laser light

    S. Perni, P. Prokopovich, C. Piccirillo, J. Pratten, I. P. Parkin and M. Wilson, J. Mater. Chem., 2009, 19, 2715
    DOI: 10.1039/B820561B

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