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Issue 16, 2009
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Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

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Abstract

We report on the therapeutic ability of a novel cyclodextrin-covered gold nanoparticle (AuNP) carrier for noncovalent encapsulation of an anti-cancer drug. The surface of the AuNPs was functionalized with cyclodextrin as a drug pocket, anti-epidermal growth factor receptor (anti-EGFR) antibody as a targeting moiety, and poly(ethyleneglycol) (PEG) as an anti-fouling shell. β-Lapachone, an anti-cancer drug, was efficiently encapsulated into the hydrophobic cavity of cyclodextrin on the surface of the AuNP carriers (AuNP-1). The glutathione-mediated release of β-lapachone from the surface of AuNP-1 was demonstrated by an experiment with MCF-7 (low glutathione concentration) and A549 cells (high glutathione concentration). We also show that the introduction of an anti-EGFR antibody onto the AuNP carriers (AuNP-2) increased the intracellular uptake of AuNP carriers as compared with AuNP-1, which does not contain a targeting ligand. In the in vitro cytotoxicity study, AuNP-2 with β-lapachone exhibited a higher apoptosis effect than that caused by AuNP-1 with β-lapachone. This work suggests that AuNPs covered with cyclodextrin and tumor-targeting ligands may find useful applications for the development of nanoparticles with therapeutic and diagnostic modalities.

Graphical abstract: Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

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Publication details

The article was received on 16 Sep 2008, accepted on 12 Jan 2009 and first published on 27 Feb 2009


Article type: Paper
DOI: 10.1039/B816209C
Citation: J. Mater. Chem., 2009,19, 2310-2315
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    Cyclodextrin-covered gold nanoparticles for targeted delivery of an anti-cancer drug

    C. Park, H. Youn, H. Kim, T. Noh, Y. H. Kook, E. T. Oh, H. J. Park and C. Kim, J. Mater. Chem., 2009, 19, 2310
    DOI: 10.1039/B816209C

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