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Issue 15, 2009
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Fabrication of Gd2O(CO3)2·H2O/silica/gold hybrid particles as a bifunctional agent for MR imaging and photothermal destruction of cancer cells

Kuo-Wei Hu,a  Fang-Yu Jhang,a  Chia-Hao Suabc  and  Chen-Sheng Yeh*a 
Author affiliations

* Corresponding authors

a Department of Chemistry, National Cheng Kung University, No 1. University Road, Tainan City
E-mail: csyeh@mail.ncku.edu.tw

b Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei

c National Taiwan University Research Center for Medical Excellence, College of Medicine, National Taiwan University, Taipei

Abstract

Bifunctional Gd2O(CO3)2·H2O/silica/Au hybrid particles were synthesized. The Gd2O(CO3)2·H2O cores were decorated with a silica layer on the surface through the condensation of TEOS and reaction with APTES to produce Gd2O(CO3)2·H2O/silica hybrid particles. The silica-coated particles were then conjugated with gold nanoparticles serving as seeds to react with HAuCl4 solution for the formation of Au shells leading to Gd2O(CO3)2·H2O/silica/Au hybrid particles. The thickness of the Au shells were set to 12, 26, 63 nm by adjusting the HAuCl4 amount. For in vitro MRI measurements, the T1-weighted performance was significantly affected by the Au shell thickness. The relaxivity r1 increased as the Au shell thickness decreased; 12 nm Au shell particles had the highest r1 value. The hybrid particles also showed the capability of absorbing near-infrared (NIR) radiation for photothermal destruction of cancer cells. It was found that the Au shell thickness also strongly influenced the NIR optical absorption and photothermal effect. At a fixed particle number, particles with a 63 nm Au shell exhibited the best photothermal performance. When the particle weight was fixed, 12 nm Au shell particles led to the optimum photothermal cancer destruction. Gd2O(CO3)2·H2O/silica/Au hybrid particles demonstrated potential as a MR imaging and therapeutic agent.

Graphical abstract: Fabrication of Gd2O(CO3)2·H2O/silica/gold hybrid particles as a bifunctional agent for MR imaging and photothermal destruction of cancer cells

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Publication details

The article was received on 29 Aug 2008, accepted on 12 Jan 2009 and first published on 12 Feb 2009


Article type: Paper
DOI: 10.1039/B815087G
Citation: J. Mater. Chem., 2009,19, 2147-2153
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    Fabrication of Gd2O(CO3)2·H2O/silica/gold hybrid particles as a bifunctional agent for MR imaging and photothermal destruction of cancer cells

    K. Hu, F. Jhang, C. Su and C. Yeh, J. Mater. Chem., 2009, 19, 2147
    DOI: 10.1039/B815087G

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