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Issue 13, 2009
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Functional DNA directed assembly of nanomaterials for biosensing

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This review summarizes recent progress in the development of biosensors by integrating functional DNA molecules with different types of nanomaterials, including metallic nanoparticles, semiconductor nanoparticles, magnetic nanoparticles, and carbon nanotubes. On one hand, advances in nanoscale science and technology have generated nanomaterials with unique optical, electrical, magnetic and catalytic properties. On the other hand, recent progress in biology has resulted in functional DNAs, a new class of DNAs that can either bind to a target molecule (known as aptamers) or perform catalytic reactions (known as DNAzymes) with the ability to recognize a broad range of targets from metal ions to organic molecules, proteins and cells specifically. By taking advantage of the strengths in both fields, the physical and chemical properties of nanomaterials have been modulated by the target recognition and catalytic activity of functional DNAs in the presence of a target analyte, resulting in a large number of colorimetric, fluorescent, electrochemical, surface-enhanced Raman scattering and magnetic resonance imaging sensors for the detection of a broad range of analytes with high sensitivity and selectivity.

Graphical abstract: Functional DNA directed assembly of nanomaterials for biosensing

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Publication details

The article was received on 11 Aug 2008, accepted on 31 Oct 2008 and first published on 20 Jan 2009

Article type: Feature Article
DOI: 10.1039/B813939C
Citation: J. Mater. Chem., 2009,19, 1788-1798
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    Functional DNA directed assembly of nanomaterials for biosensing

    Z. Wang and Y. Lu, J. Mater. Chem., 2009, 19, 1788
    DOI: 10.1039/B813939C

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