Jump to main content
Jump to site search

Issue 3, 2009
Previous Article Next Article

Towards thrombosis-targeted zeolite nanoparticles for laser-polarized 129Xe MRI

Author affiliations

Abstract

The synthesis and functionalisation of zeolite nanoparticles designed for laser-polarized 129Xe NMR experiments in solution are described. These nanoparticles were functionalized by using original synthesis pathways through semicarbazide COCHO chemistry in order to ensure anchoring of a peptide for targeting biological receptors and attachment of PEG chains for in vivo experiments. Results demonstrated that accessibility of the dissolved noble gas to the micropores was maintained after functionalization. γ Scintigraphy with 111In linked to the zeolite particles has been investigated in order to follow the behaviour of the zeolite nanoparticles in mice. These preliminary 111In scintigraphy experiments showed the localization of the nanoparticles after injection in mice and their biodistribution, as a first proof-of-concept towards in vivo129Xe MRI.

Graphical abstract: Towards thrombosis-targeted zeolite nanoparticles for laser-polarized 129Xe MRI

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Jun 2008, accepted on 23 Oct 2008 and first published on 24 Nov 2008


Article type: Paper
DOI: 10.1039/B810253H
Citation: J. Mater. Chem., 2009,19, 379-386
  •   Request permissions

    Towards thrombosis-targeted zeolite nanoparticles for laser-polarized 129Xe MRI

    F. Lerouge, O. Melnyk, J. Durand, L. Raehm, P. Berthault, G. Huber, H. Desvaux, A. Constantinesco, P. Choquet, J. Detour and M. Smaïhi, J. Mater. Chem., 2009, 19, 379
    DOI: 10.1039/B810253H

Search articles by author

Spotlight

Advertisements