Jump to main content
Jump to site search

Issue 11, 2009
Previous Article Next Article

Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water

Author affiliations

Abstract

A green, rapid, and efficient method was developed for synthesizing quinazolinone derivatives from substituted 2-halobenzoic acids and amidines via microwave-assisted iron-catalyzed cyclization with or without ligand in water (methods A and B) or DMF (methods C and D). With these methods, moderate to high yields of the desired products can be obtained from even inactive substrates, such as guanidines. To the best of our knowledge, this is the first report on the synthesis of N-heterocyclic compounds by iron-catalyzed C–N coupling in aqueous media.

Graphical abstract: Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jun 2009, accepted on 10 Aug 2009 and first published on 08 Sep 2009


Article type: Paper
DOI: 10.1039/B916124B
Citation: Green Chem., 2009,11, 1881-1888
  •   Request permissions

    Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water

    X. Zhang, D. Ye, H. Sun, D. Guo, J. Wang, H. Huang, X. Zhang, H. Jiang and H. Liu, Green Chem., 2009, 11, 1881
    DOI: 10.1039/B916124B

Search articles by author

Spotlight

Advertisements