Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water

Xiaodong Zhang; Deju Ye; Haifeng Sun; Diliang Guo; Jiang Wang; He Huang; Xu Zhang; Hualiang Jiang; Hong Liu

doi:10.1039/B916124B

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Green Chemistry

Issue 11, 2009

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Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water

Xiaodong Zhang , Deju Ye , Haifeng Sun , Diliang Guo , Jiang Wang , He Huang , Xu Zhang , Hualiang Jiang and Hong Liu

Green Chem., 2009, 11, 1881-1888

DOI: 10.1039/B916124B
Received 22 Jun 2009, Accepted 10 Aug 2009
First published on the web 08 Sep 2009

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Abstract
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A green, rapid, and efficient method was developed for synthesizing quinazolinone derivatives from substituted 2-halobenzoic acids and amidines via microwave-assisted iron-catalyzed cyclization with or without ligand in water (methods A and B) or DMF (methods C and D). With these methods, moderate to high yields of the desired products can be obtained from even inactive substrates, such as guanidines. To the best of our knowledge, this is the first report on the synthesis of N-heterocyclic compounds by iron-catalyzed C–N coupling in aqueous media.

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Articles By

Xiaodong Zhang
Deju Ye
Haifeng Sun
Diliang Guo
Jiang Wang
He Huang
Xu Zhang
Hualiang Jiang
Hong Liu

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Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water

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