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Issue 12, 2009
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An environmentally benign catalytic oxidation of cholesteryl acetate with molecular oxygen by using N-hydroxyphthalimide

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Abstract

A green and effective method is reported for the oxidation of cholesteryl acetate to 7-keto-cholesteryl acetate with O2 in the presence of catalytic amounts of N-hydroxyphthalimide (NHPI) under mild conditions. It was found that Co(OAc)2 could cooperate with Mn(OAc)2 to enhance the catalytic ability of NHPI resulting in better yields. This economical and environmentally-friendly method provides a potentially new way for the synthesis of the intermediate product of vitamin D3 in industry, which eliminates the use of large amounts of bromine in present route and overcomes the drawbacks of the known oxidation methods.

Graphical abstract: An environmentally benign catalytic oxidation of cholesteryl acetate with molecular oxygen by using N-hydroxyphthalimide

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Publication details

The article was received on 03 Aug 2009, accepted on 07 Sep 2009 and first published on 12 Oct 2009


Article type: Paper
DOI: 10.1039/B915737A
Citation: Green Chem., 2009,11, 2013-2017
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    An environmentally benign catalytic oxidation of cholesteryl acetate with molecular oxygen by using N-hydroxyphthalimide

    Z. Yao, X. Hu, J. Mao and H. Li, Green Chem., 2009, 11, 2013
    DOI: 10.1039/B915737A

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