Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

Heiko Leutbecher; Szilvia Hajdok; Christina Braunberger; Melanie Neumann; Sabine Mika; Jürgen Conrad; Uwe Beifuss

doi:10.1039/B822977E

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Green Chemistry

Issue 5, 2009

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Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

Heiko Leutbecher , Szilvia Hajdok , Christina Braunberger , Melanie Neumann , Sabine Mika , Jürgen Conrad and Uwe Beifuss

Green Chem., 2009, 11, 676-679

DOI: 10.1039/B822977E
Received 24 Dec 2008, Accepted 18 Feb 2009
First published on the web 27 Feb 2009

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The enzymes tyrosinase and laccase from a crude extract of the button mushroom (Agaricus bisporus) can be employed to catalyze the domino reaction between phenol and various cyclic 1,3-dicarbonyls using atmospheric oxygen as the oxidizing agent and yielding annulated benzofuranes in a highly efficient and sustainable manner.

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Articles By

Heiko Leutbecher
Szilvia Hajdok
Christina Braunberger
Melanie Neumann
Sabine Mika
Jürgen Conrad
Uwe Beifuss

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Green Chemistry

Combined action of enzymes: the first domino reaction catalyzed by Agaricus bisporus

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