Issue 6, 2009
From the journal:

Green Chemistry

Highly enantioselective hydrogenation of quinolines under solvent-free or highly concentrated conditions†

Zhi-Jian Wang,‡a   Hai-Feng Zhou,‡a   Tian-Li Wang,a   Yan-Mei Hea  and  Qing-Hua Fan*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry and Graduate School, Chinese Academy of Sciences, Beijing, China
E-mail: fanqh@iccas.ac.cn

Abstract

The phosphine-free chiral cationic Ru(OTf)(TsDPEN)(η6-cymene) complex was found to be an efficient catalyst for the enantioselective hydrogenation of quinolines under more environmentally friendly solvent-free or highly concentrated conditions. Excellent yields and enantioselectivities (up to 97% ee) were obtained at only 0.02–0.10 mol% catalyst loading.

Graphical abstract: Highly enantioselective hydrogenation of quinolines under solvent-free or highly concentrated conditions

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Article information

DOI
https://doi.org/10.1039/B822822A
Article type
Communication
Submitted
19 Dec 2008
Accepted
10 Mar 2009
First published
18 Mar 2009

Green Chem., 2009,11, 767-769

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Highly enantioselective hydrogenation of quinolines under solvent-free or highly concentrated conditions

Z. Wang, H. Zhou, T. Wang, Y. He and Q. Fan, Green Chem., 2009, 11, 767 DOI: 10.1039/B822822A

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