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Issue 4, 2009
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Long term continuous chemoenzymatic dynamic kinetic resolution of rac-1-phenylethanol using ionic liquids and supercritical carbon dioxide

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Abstract

The long term continuous dynamic kinetic resolution (DKR) of rac-phenylethanol in IL/scCO2 biphasic systems was carried out by simultaneously using immobilized lipase (Novozym 435) and acidic zeolite catalysts at 50 °C and 100 bar, providing good yields (up to 98.0%) for R-phenylethyl propionate with excellent enantioselectivity (up to 97.3% ee) and without any activity loss during 14 days of operation.

Graphical abstract: Long term continuous chemoenzymatic dynamic kinetic resolution of rac-1-phenylethanol using ionic liquids and supercritical carbon dioxide

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Publication details

The article was received on 02 Dec 2008, accepted on 19 Jan 2009 and first published on 13 Feb 2009


Article type: Paper
DOI: 10.1039/B821623A
Citation: Green Chem., 2009,11, 538-542
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    Long term continuous chemoenzymatic dynamic kinetic resolution of rac-1-phenylethanol using ionic liquids and supercritical carbon dioxide

    P. Lozano, T. De Diego, C. Mira, K. Montague, M. Vaultier and J. L. Iborra, Green Chem., 2009, 11, 538
    DOI: 10.1039/B821623A

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