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Issue 48, 2009
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Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

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Abstract

A number of new ruthenium compounds have been synthesised, isolated and characterised, which exhibit excellent cytotoxicity against a number of different human tumour cell lines including a defined cisplatin resistant cell line and colon cancer cell lines. Addition of hydrophobic groups to the ruthenium molecules has a positive effect on the cytotoxicity values. Evidence is provided that, after incubation of a ruthenium compound with a 46 mer oligonucleotide duplex and subsequent nuclease treatment, ruthenium is bound to a guanine residue.

Graphical abstract: Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

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Publication details

The article was received on 14 Sep 2009, accepted on 29 Oct 2009 and first published on 16 Nov 2009


Article type: Paper
DOI: 10.1039/B918902E
Citation: Dalton Trans., 2009,0, 10914-10925
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    Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

    K. D. Camm, A. El-Sokkary, A. L. Gott, P. G. Stockley, T. Belyaeva and P. C. McGowan, Dalton Trans., 2009, 0, 10914
    DOI: 10.1039/B918902E

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