Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

Kenneth D. Camm; Ahmed El-Sokkary; Andrew L. Gott; Peter G. Stockley; Tamara Belyaeva; Patrick C. McGowan

doi:10.1039/B918902E

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Dalton Transactions

Issue 48, 2009

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Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

Kenneth D. Camm , Ahmed El-Sokkary , Andrew L. Gott , Peter G. Stockley , Tamara Belyaeva and Patrick C. McGowan

Dalton Trans., 2009, 10914-10925

DOI: 10.1039/B918902E
Received 14 Sep 2009, Accepted 29 Oct 2009
First published on the web 16 Nov 2009
This article is part of the collection: Metal anticancer compounds

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A number of new ruthenium compounds have been synthesised, isolated and characterised, which exhibit excellent cytotoxicity against a number of different human tumour cell lines including a defined cisplatin resistant cell line and colon cancer cell lines. Addition of hydrophobic groups to the ruthenium molecules has a positive effect on the cytotoxicity values. Evidence is provided that, after incubation of a ruthenium compound with a 46 mer oligonucleotide duplex and subsequent nuclease treatment, ruthenium is bound to a guanine residue.

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Articles By

Kenneth D. Camm
Ahmed El-Sokkary
Andrew L. Gott
Peter G. Stockley
Tamara Belyaeva
Patrick C. McGowan

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Dalton Transactions

Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents

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