Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

Yong Leng Kelvin Tan; Pascal Pigeon; Elizabeth A. Hillard; Siden Top; Marie-Aude Plamont; Anne Vessières; Michael J. McGlinchey; Helge Müller-Bunz; Gérard Jaouen

doi:10.1039/B913570G

skip RSC | ChemSpider | Feedback

Home > Journals > Dalton Transactions > Synthesis, oxidation ch...

Authors & Referees | Librarians

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Dalton Transactions

Issue 48, 2009

More about this Journal
Editorial Board
Submit an Article

Follow Journal | |

Journal Home | RSC Journals

Paper

Previous Article | Next Article

Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

Yong Leng Kelvin Tan , Pascal Pigeon , Elizabeth A. Hillard , Siden Top , Marie-Aude Plamont , Anne Vessières , Michael J. McGlinchey , Helge Müller-Bunz and Gérard Jaouen

Dalton Trans., 2009, 10871-10881

DOI: 10.1039/B913570G
Received 08 Jul 2009, Accepted 01 Oct 2009
First published on the web 27 Oct 2009
This article is part of the collection: Metal anticancer compounds

Please wait while Download options loads

Request Permissions

Abstract
Cited by
Compounds
Related Content

A series of compounds is described in which one of the ethyl groups in diethylstilbestrol has been replaced by a ferrocenyl substituent. Only those derivatives incorporating phenol moieties underwent isomerisation from the Z to the E form, and some of them could be chemically oxidized to a quinone species. The compounds were less cytotoxic against hormone-independent MDA-MB-231 breast cancer cell lines than their corresponding ferrocenyl phenyl or phenol isomers in which the ferrocene and ethyl moieties are linked to the same carbon atom. The biochemical results were evaluated in conjunction with information obtained from electrochemical and chemical oxidation experiments.

This may take some time to load.

Supplementary Info

Additional information
PDF (1315K)
Crystal structure data
TXT (119K)

Articles By

Yong Leng Kelvin Tan
Pascal Pigeon
Elizabeth A. Hillard
Siden Top
Marie-Aude Plamont
Anne Vessières
Michael J. McGlinchey
Helge Müller-Bunz
Gérard Jaouen

Terms & Conditions|Privacy |Accessibility|ACAP Enabled

Dalton Transactions

Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol

Log in (Free Access)

Log in (Subscriber Access)

Supplementary Info

Articles By