Synthesis of ferrocene tethered open and macrocyclic bis-β-lactams and bis-β-amino acid derivatives

Miguel A. Sierra; Mamen Rodríguez-Fernández; Luis Casarrubios; Mar Gómez-Gallego; Charles P. Allen; María José Mancheño

doi:10.1039/B911450E

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Dalton Transactions

Issue 39, 2009

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Synthesis of ferrocene tethered open and macrocyclic bis-β-lactams and bis-β-amino acid derivatives

Miguel A. Sierra , Mamen Rodríguez-Fernández , Luis Casarrubios , Mar Gómez-Gallego , Charles P. Allen and María José Mancheño

Dalton Trans., 2009, 8399-8405

DOI: 10.1039/B911450E
Received 12 Jun 2009, Accepted 11 Aug 2009
First published on the web 02 Sep 2009

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Abstract
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New bioorganometallic ferrocene derivatives are synthesized through a Diversity Oriented Synthesis strategy. Easily available ferrocene bisimines have been transformed into open ferrocenyl bis-β-lactams. These compounds have demonstrated to be versatile synthons used in further transformations into new ferrocene bis-β-amino acids. Carefully selected substituents submitted to ring closing metathesis (RCM) and Cu-catalyzed oxidative alkyne coupling conditions have also allowed the conversion of open substrates into ferrocenic macrocyclic bis-β-lactams.

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Articles By

Miguel A. Sierra
Mamen Rodríguez-Fernández
Luis Casarrubios
Mar Gómez-Gallego
Charles P. Allen
María José Mancheño

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Dalton Transactions

Synthesis of ferrocene tethered open and macrocyclic bis-β-lactams and bis-β-amino acid derivatives

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