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Issue 35, 2009
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Metal-NHC complexes: a survey of anti-cancer properties

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Abstract

New weapons to fight cancer are constantly needed. Among chemotherapeutics, anti-cancer metal-drugs have enjoyed a long and successful history since the discovery of the benchmark cisplatin. Advances in metal-drug discovery have motivated chemists to build plethora of complex structures. Among them, a novel area is emerging. This article presents a survey of the metal-N-Heterocyclic Carbenes (Ag(I), Au(I), Pd(II) and Cu(I)-NHCs) as potential anti-cancer agents. Most of the metal-NHCs considered display higher cytotoxicities than the reference metallo-drug cisplatin. Some of them are even selective for particular cell lines. Their mechanisms of action at the cellular level are further discussed, showing that the nature of the metal is of great importance. All these promising results demonstrate that this approach deserves more attention and work.

Graphical abstract: Metal-NHC complexes: a survey of anti-cancer properties

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Publication details

The article was received on 30 Mar 2009, accepted on 10 Jun 2009 and first published on 10 Jul 2009


Article type: Perspective
DOI: 10.1039/B906308K
Citation: Dalton Trans., 2009,0, 6894-6902
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    Metal-NHC complexes: a survey of anti-cancer properties

    M. Teyssot, A. Jarrousse, M. Manin, A. Chevry, S. Roche, F. Norre, C. Beaudoin, L. Morel, D. Boyer, R. Mahiou and A. Gautier, Dalton Trans., 2009, 0, 6894
    DOI: 10.1039/B906308K

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