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Issue 38, 2009
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Bis- and tris(pyridyl)amine-oxidovanadium complexes: Characteristics and insulin-mimetic potential

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Abstract

Two novel vanadium complexes, [VIVO(bp-O)(HSO4)] (1) and [VIVO(bp-OH)Cl2]·CH3OH (2·CH3OH), where bp-OH is 2-{[bis(pyrid-2-yl)methyl]amine}methylphenol, were prepared and structurally characterised. EPR spectra of methanol solutions of 2 suggest exchange of Cl for CH3OH and partial conversion to [VO(bp-OH)(CH3OH)3]2+. Speciation studies on the VO2+-bpOH system in a water/dmso mixture (4:1 v/v) revealed [VO(bp-O)(H2O)n]+ as the dominating species in the pH range 2–7. The insulin-mimetic properties of 1 and 2, [VIVO(SO4)tpa] (3), [VIVO(pic-trpMe)2] (5) and the new mixed-ligand complexes [VVO(pic-trpH)tpa]Cl2 (4Cl2) and [VVO(pic-OEt)tpa]Cl2 (6Cl2), tpa = tris(pyrid-2-yl)methylamine, picH-trpH = 2-carboxypyridine-5-(L-tryptophan)carboxamide (picH-trpMe is the respective tryptophanmethyl ester), pic-OEt = 5-carboethoxypyridine-2-carboxylic acid, were evaluated with rat adipocytes, employing two lipolysis assays (release of glycerol and free fatty acids (FFA)), respectively and a lipogenesis assay (incorporation of glucose into lipids). The IC50 values for the inhibition of lipolysis in the FFA assay vary between 0.41 (±0.03) (5) and 21.2 (±0.6) mM (2), as compared to 0.81 (±0.2) mM for VOSO4.

Graphical abstract: Bis- and tris(pyridyl)amine-oxidovanadium complexes: Characteristics and insulin-mimetic potential

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Publication details

The article was received on 20 Feb 2009, accepted on 22 May 2009 and first published on 05 Aug 2009


Article type: Paper
DOI: 10.1039/B903456K
Citation: Dalton Trans., 2009,0, 7902-7911
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    Bis- and tris(pyridyl)amine-oxidovanadium complexes: Characteristics and insulin-mimetic potential

    J. Nilsson, E. Degerman, M. Haukka, G. C. Lisensky, E. Garribba, Y. Yoshikawa, H. Sakurai, E. A. Enyedy, T. Kiss, H. Esbak, D. Rehder and E. Nordlander, Dalton Trans., 2009, 0, 7902
    DOI: 10.1039/B903456K

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