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Issue 14, 2009
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Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent

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Abstract

A layered gadolinium hydroxychloride (LGdH), [Gd2(OH)5(H2O)x]Cl, was synthesized from an aqueous solution of GdCl3·6H2O. The X-ray diffraction (XRD) and the selected area electron diffraction (SAED) studies showed that this compound crystallizes in the orthorhombic structure (a = 12.88(4) Å, b = 7.30(2) Å, and c = 8.46(3) Å) which is isostructural with [Eu2(OH)5(H2O)x]Cl. Interestingly, this layered material was readily dispersed and led to a stable colloidal nanosheet in aqueous medium. The obtained colloidal solutions were characterized by the evaluation of their stability in acidic solution, their in vitro cytotoxicity, and their magnetic resonance imaging (MRI) relaxation properties. It is reported that the relaxometry analysis of LGdH suspensions exhibits a sufficient contrast effect for T1 weighted magnetic resonance imaging.

Graphical abstract: Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent

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Publication details

The article was received on 24 Dec 2008, accepted on 19 Jan 2009 and first published on 13 Feb 2009


Article type: Paper
DOI: 10.1039/B823172A
Citation: Dalton Trans., 2009,0, 2490-2495
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    Synthesis of colloidal aqueous suspensions of a layered gadolinium hydroxide: a potential MRI contrast agent

    B. Lee, K. S. Lee, J. H. Lee, I. S. Lee and S. Byeon, Dalton Trans., 2009, 0, 2490
    DOI: 10.1039/B823172A

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