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Issue 10, 2009
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Genetically encoded biosensors based on engineered fluorescent proteins

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Abstract

Fluorescent proteins have revolutionized cell biology by allowing researchers to non-invasively peer into the inner workings of cells and organisms. While the most common applications of fluorescent proteins are to image expression, localization, and dynamics of protein chimeras, there is a growing interest in using fluorescent proteins to create biosensors for minimally invasive imaging of concentrations of ions and small molecules, the activity of enzymes, and changes in the conformation of proteins in living cells. This tutorial review provides an overview of the progress made in the development of fluorescent protein-based biosensors to date.

Graphical abstract: Genetically encoded biosensors based on engineered fluorescent proteins

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Publication details

The article was received on 20 Apr 2009 and first published on 04 Aug 2009


Article type: Tutorial Review
DOI: 10.1039/B907749A
Citation: Chem. Soc. Rev., 2009,38, 2833-2841
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    Genetically encoded biosensors based on engineered fluorescent proteins

    W. B. Frommer, M. W. Davidson and R. E. Campbell, Chem. Soc. Rev., 2009, 38, 2833
    DOI: 10.1039/B907749A

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