Amide bond formation: beyond the myth of coupling reagents

Eric Valeur; Mark Bradley

doi:10.1039/B701677H

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Chemical Society Reviews

Issue 2, 2009

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Amide bond formation: beyond the myth of coupling reagents

Eric Valeur and Mark Bradley

Chem. Soc. Rev., 2009, 38, 606-631

DOI: 10.1039/B701677H
Received 23 Jun 2008, First published on the web 04 Dec 2008

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Amide bond formation is a fundamentally important reaction in organic synthesis, and is typically mediated by one of a myriad of so-called coupling reagents. This critical review is focussed on the most recently developed coupling reagents with particular attention paid to the pros and cons of the plethora of “acronym” based reagents. It aims to demystify the process allowing the chemist to make a sensible and educated choice when carrying out an amide coupling reaction (179 references).

Abstract from Methods in Organic Synthesis 2009

A review, with 179 references, of recently developed reagents for the formation of amide bonds.

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Amide bond formation: beyond the myth of coupling reagents

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