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Issue 45, 2009
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Viral assembly: a molecular modeling perspective

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Abstract

Icosahedral viruses are among the smallest and simplest of biological systems. The investigation of their structures represented the first step toward the establishment of molecular biophysics, over half a century ago. Many research groups are now pursuing investigations of viral assembly, a process that could offer new opportunities for the design of antiviral drugs and novel nanoparticles. A variety of experimental, theoretical and computational methods have been brought to bear on the study of virus structure and assembly. In this Perspective we review the contributions of theoretical and computational approaches to our understanding of the structure, energetics, thermodynamics and assembly of DNA bacteriophage and single-stranded icosahedral RNA viruses.

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Publication details

The article was received on 02 Jul 2009, accepted on 28 Sep 2009 and first published on 19 Oct 2009


Article type: Perspective
DOI: 10.1039/B912884K
Citation: Phys. Chem. Chem. Phys., 2009,11, 10553-10564
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    Viral assembly: a molecular modeling perspective

    S. C. Harvey, A. S. Petrov, B. Devkota and M. B. Boz, Phys. Chem. Chem. Phys., 2009, 11, 10553
    DOI: 10.1039/B912884K

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