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Issue 12, 2009
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Multiscale modeling of emergent materials: biological and soft matter

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Abstract

In this review, we focus on four current related issues in multiscale modeling of soft and biological matter. First, we discuss how to use structural information from detailed models (or experiments) to construct coarse-grained ones in a hierarchical and systematic way. This is discussed in the context of the so-called Henderson theorem and the inverse Monte Carlo method of Lyubartsev and Laaksonen. In the second part, we take a different look at coarse graining by analyzing conformations of molecules. This is done by the application of self-organizing maps, i.e., a neural network type approach. Such an approach can be used to guide the selection of the relevant degrees of freedom. Then, we discuss technical issues related to the popular dissipative particle dynamics (DPD) method. Importantly, the potentials derived using the inverse Monte Carlo method can be used together with the DPD thermostat. In the final part we focus on solvent-free modeling which offers a different route to coarse graining by integrating out the degrees of freedom associated with solvent.

Graphical abstract: Multiscale modeling of emergent materials: biological and soft matter

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Publication details

The article was received on 14 Oct 2008, accepted on 12 Feb 2009 and first published on 25 Feb 2009


Article type: Perspective
DOI: 10.1039/B818051B
Citation: Phys. Chem. Chem. Phys., 2009,11, 1869-1892
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    Multiscale modeling of emergent materials: biological and soft matter

    T. Murtola, A. Bunker, I. Vattulainen, M. Deserno and M. Karttunen, Phys. Chem. Chem. Phys., 2009, 11, 1869
    DOI: 10.1039/B818051B

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