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Issue 7, 2009
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Self-assembled dithiothreitol on Au surfaces for biological applications: phospholipid bilayer formation

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Abstract

Self-assembly of dithiothreitol (DTT) on Au(111) from solution deposition has been studied by X-ray photoelectron spectroscopy and electrochemical data. DTT molecules self-assemble on Au(111) in a lying-down configuration irrespective of the concentration and temperature. XPS and electrochemical data indicate a DTT surface coverage of θ≈ 0.16 with two S-head–Au covalent bonds per DTT molecule. The DTT monolayer turns the Au surface hydrophilic enough to allow the formation of fluid dimyristoylphosphatidylcholine (DMPC) bilayer domains by vesicle fusion as revealed by in situatomic force imaging. Methylene blue (MB) and flavin adenine dinucleotide (FAD) have been used as probes to study molecule transport across the bilayer.

Graphical abstract: Self-assembled dithiothreitol on Au surfaces for biological applications: phospholipid bilayer formation

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Publication details

The article was received on 17 Jul 2008, accepted on 05 Nov 2008 and first published on 24 Dec 2008


Article type: Paper
DOI: 10.1039/B811964C
Citation: Phys. Chem. Chem. Phys., 2009,11, 1077-1084
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    Self-assembled dithiothreitol on Au surfaces for biological applications: phospholipid bilayer formation

    T. B. Creczynski-Pasa, M. A. D. Millone, M. L. Munford, V. R. de Lima, T. O. Vieira, G. A. Benitez, A. A. Pasa, R. C. Salvarezza and M. E. Vela, Phys. Chem. Chem. Phys., 2009, 11, 1077
    DOI: 10.1039/B811964C

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