Issue 11, 2009

Polymorphism and versatile solvate formation of thiophanate-methyl

Abstract

The polymorphism of a fungicide, thiophanate-methyl (TM), was investigated with conventional solvent screening methods. Two polymorphs, the thermodynamically most stable form I and the less stable form II, were found. TM was also found to crystallize as a plethora of different solvates which produced mostly form II upon desolvation. The structures of form I and form II and the fourteen discovered solvates were solved by single crystal X-ray diffraction. The most stable forms were further characterized by powder diffraction, thermoanalytical (TG/DTA, DSC and thermomicroscopy) and spectroscopic (IR, Raman, 13C CP/MAS NMR) methods.

Graphical abstract: Polymorphism and versatile solvate formation of thiophanate-methyl

Supplementary files

Article information

Article type
Paper
Submitted
18 Mar 2009
Accepted
14 Jul 2009
First published
07 Aug 2009

CrystEngComm, 2009,11, 2536-2547

Polymorphism and versatile solvate formation of thiophanate-methyl

E. Nauha, H. Saxell, M. Nissinen, E. Kolehmainen, A. Schäfer and R. Schlecker, CrystEngComm, 2009, 11, 2536 DOI: 10.1039/B905511H

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