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Issue 2, 2009
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Putting pressure on elusive polymorphs and solvates

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Abstract

The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce ‘bulk’ quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.

Graphical abstract: Putting pressure on elusive polymorphs and solvates

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Publication details

The article was received on 20 Aug 2008, accepted on 28 Oct 2008 and first published on 28 Nov 2008


Article type: Paper
DOI: 10.1039/B814471K
Citation: CrystEngComm, 2009,11, 359-366
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    Putting pressure on elusive polymorphs and solvates

    I. D. H. Oswald, I. Chataigner, S. Elphick, F. P. A. Fabbiani, A. R. Lennie, J. Maddaluno, W. G. Marshall, T. J. Prior, C. R. Pulham and R. I. Smith, CrystEngComm, 2009, 11, 359
    DOI: 10.1039/B814471K

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