Radiolabelling of proteins with fluorine-18 via click chemistry

Theres Ramenda; Torsten Kniess; Ralf Bergmann; Jörg Steinbach; Frank Wuest

doi:10.1039/B916075B

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Chemical Communications

Issue 48, 2009

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Radiolabelling of proteins with fluorine-18 via click chemistry

Theres Ramenda , Torsten Kniess , Ralf Bergmann , Jörg Steinbach and Frank Wuest

Chem. Commun., 2009, 7521-7523

DOI: 10.1039/B916075B
Received 05 Aug 2009, Accepted 20 Oct 2009
First published on the web 04 Nov 2009

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Abstract
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The study describes for the first time the application of Cu(I)-mediated 1,3-dipolar [3+2]cycloaddition for the labelling of proteins with the short-lived positron emitter fluorine-18 as exemplified with azide-functionalized human serum albumin (HSA).

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Theres Ramenda
Torsten Kniess
Ralf Bergmann
Jörg Steinbach
Frank Wuest

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Chemical Communications

Radiolabelling of proteins with fluorine-18 via click chemistry

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