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Issue 42, 2009
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Gd(DO3A-N-α-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

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Abstract

We report the synthesis of a novel, versatile and easily accessible metal chelator, DO3A-N-α-aminopropionate, and the relaxometric characterization of its Gd3+ complex, revealing great potential for the development of high relaxivity targeted contrast agents for magnetic resonance imaging.

Graphical abstract: Gd(DO3A-N-α-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

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Publication details

The article was received on 22 Jun 2009, accepted on 14 Aug 2009 and first published on 09 Sep 2009


Article type: Communication
DOI: 10.1039/B912201J
Citation: Chem. Commun., 2009, 6475-6477
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    Gd(DO3A-N-α-aminopropionate): a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents

    M. F. Ferreira, A. F. Martins, J. A. Martins, P. M. Ferreira, É. Tóth and C. F.G.C. Geraldes, Chem. Commun., 2009, 6475
    DOI: 10.1039/B912201J

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