A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

Tae-Il Kim; Hyo Jin Kang; Garam Han; Sang J. Chung; Youngmi Kim

doi:10.1039/B911145J

A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

Tae-Il Kim,^a Hyo Jin Kang,^b Garam Han,^a Sang J. Chung*^b and Youngmi Kim*^a

* Corresponding authors

^a Department of Chemistry, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do, Korea
E-mail: youngmi@dankook.ac.kr
Fax: +82 31-8005-3148
Tel: +82 31-8005-3156

^b BioNanotechnology Research Center, KRIBB, and Nanobio Division, UST, 52 Eoeun-dongYuseong, Daejeon 305-333, Korea
E-mail: sjchung@kribb.re.kr
Fax: +82 42-879-8594
Tel: +82 42-879-8433

Abstract

A highly selective fluorescent probe for a protein tyrosine phosphatase (PTP) was designed by a simple phosphorylation of the 2-(2′-hydroxyphenyl)benzothiazole (HBT) chromophore: upon selective enzymatic hydrolysis, an excited-state intramolecular proton transfer (ESIPT) occurs, resulting in a large Stokes shift.

Supplementary files

Publication details

The article was received on 08 Jun 2009, accepted on 24 Jul 2009 and first published on 17 Aug 2009

Article type: Communication

DOI: 10.1039/B911145J

Citation: Chem. Commun., 2009,0, 5895-5897

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A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

T. Kim, H. J. Kang, G. Han, S. J. Chung and Y. Kim, Chem. Commun., 2009, 0, 5895
DOI: 10.1039/B911145J
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Chemical Communications

A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

Abstract

Supplementary files

Publication details

A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

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