Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

Jacqueline A. I. Smith; Jingxin Wang; Sao-Mai Nguyen-Mau; Vincent Lee; Herman O. Sintim

doi:10.1039/B909666C

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Chemical Communications

Issue 45, 2009

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Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

Jacqueline A. I. Smith , Jingxin Wang , Sao-Mai Nguyen-Mau , Vincent Lee and Herman O. Sintim

Chem. Commun., 2009, 7033-7035

DOI: 10.1039/B909666C
Received 15 May 2009, Accepted 21 Sep 2009
First published on the web 13 Oct 2009

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C1-alkyl AI-2 analogues do not induce bioluminescence in V. harveyi on their own but enhance the bioluminescence induced by AI-2 in a synergistic fashion. A new facile synthesis of AI-2 facilitates the synthesis of a diverse set of AI-2 analogues and biological screening suggests that receptors that are involved in the synergistic bioluminescence production in V. harveyi are promiscuous.

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Characterization of new compounds
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Jacqueline A. I. Smith
Jingxin Wang
Sao-Mai Nguyen-Mau
Vincent Lee
Herman O. Sintim

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Chemical Communications

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

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