Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA

Linlin Zhao; John B. Schenkman; James F. Rusling

doi:10.1039/B909372A

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Chemical Communications

Issue 36, 2009

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Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA

Linlin Zhao , John B. Schenkman and James F. Rusling

Chem. Commun., 2009, 5386-5388

DOI: 10.1039/B909372A
Received 12 May 2009, Accepted 04 Aug 2009
First published on the web 17 Aug 2009

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We demonstrate for the first time the combination of human liver cytosol and microsomal enzyme sources into an electro-optical array to screen for reactive metabolites produced in multi-enzyme metabolic processes.

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Chemical Communications

Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA

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