Phosphate-assisted peptide ligation

Gemma L. Thomas; Richard J. Payne

doi:10.1039/B906492C

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Chemical Communications

Issue 28, 2009

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Phosphate-assisted peptide ligation

Gemma L. Thomas and Richard J. Payne

Chem. Commun., 2009, 4260-4262

DOI: 10.1039/B906492C
Received 01 Apr 2009, Accepted 28 Apr 2009
First published on the web 26 May 2009

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Abstract
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A novel ligation method for the synthesis of phosphopeptides and peptides is described, which utilises the inherent reactivity of a peptide bearing an N-terminal phosphoserine or phosphothreonine residue to facilitate amide bond formation with a range of C-terminal peptide thioesters.

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Supplementary Info

Detailed procedures for the synthesis of peptides,phosphopeptides, peptide thioesters, ligation reactions anddephosphorylation reactions. Crude traces and analytical data forpeptides, phosphopeptides, peptide thioesters, ligation productsand dephosphorylated peptides
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Chemical Communications

Phosphate-assisted peptide ligation

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