Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

Nsovo S. Mathebula; Jeseelan Pillay; Gianna Toschi; Jan A. Verschoor; Kenneth I. Ozoemena

doi:10.1039/B905192A

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Chemical Communications

Issue 23, 2009

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Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

Nsovo S. Mathebula , Jeseelan Pillay , Gianna Toschi , Jan A. Verschoor and Kenneth I. Ozoemena

Chem. Commun., 2009, 3345-3347

DOI: 10.1039/B905192A
Received 13 Mar 2009, Accepted 28 Apr 2009
First published on the web 15 May 2009

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Abstract
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Electrochemical impedimetric recognition by anti-mycolic acid antibodies, present in tuberculosis (TB)-positive human serum co-infected with human immunodeficiency virus (HIV), of mycolic acids (MA) integrated into a self-assembled monolayer of N-(2-mercaptoethyl)octadecanamide on a gold electrode is described, proving that the MA-based electrode can satisfactorily discriminate between a TB-positive and a TB-negative serum, thus offering promise as a potential impedimetric immunosensing platform for active tuberculosis.

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Supplementary Info

Detailed experimental information, comparative cyclicvoltammograms and Nyquist plots of bare Au, Au–MEODA andAu–MEODA–MA; Nyquist plots of HIV⁻–TB⁻ serum; degree of inhibition vs. HIV⁺–TB⁺ serum concentrations
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Nsovo S. Mathebula
Jeseelan Pillay
Gianna Toschi
Jan A. Verschoor
Kenneth I. Ozoemena

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Chemical Communications

Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

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