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Issue 22, 2009
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Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

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Abstract

Solid-phase oligonucleotide conjugation by nitrile oxidealkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.

Graphical abstract: Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

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Publication details

The article was received on 02 Mar 2009, accepted on 09 Apr 2009 and first published on 22 Apr 2009


Article type: Communication
DOI: 10.1039/B904185K
Citation: Chem. Commun., 2009,0, 3276-3278
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    Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

    I. Singh, J. S. Vyle and F. Heaney, Chem. Commun., 2009, 0, 3276
    DOI: 10.1039/B904185K

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